After solving the structure of an enzyme from the tuberculosis bacterium, researchers from Stanford University in Palo Alto created a probe that lights up when the enzyme is present, potentially reducing false negatives inherent to the current diagnostic methods. The results were published this week (September 2) in Nature Chemistry.
Mycobacterium tuberculosis, the causative agent of tuberculosis, produces and secretes the enzyme BlaC, which breaks down proteins like β-lactams, present in many antibiotics including penicillin. Once researchers solved the enzyme’s structure, they were able to design a molecule similar to β-lactam, but which would fluoresce a bright blue glow when broken down by BlaC.
To read the full, original article click on this link: Do it Yourself TB Test | The Scientist
