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Connie John's MandalMed Inc. and two other companies moved into space on Third Street seven years ago. The space now holds a dozen companies.

While San Francisco's Mission Bay biotech cluster represents a transformation of an entire neighborhood — from rail yards to life sciences ecosystem — Connie John's Bioscience Laboratories a short walk away is trying the same thing on a smaller scale.

The 7-year-old Third Street incubator, located in the former MJB Coffee Co. building, is unknowingly passed by thousands of baseball fans as they hustle through SoMa to San Francisco Giants games. A dozen young life sciences companies — including Universal BioMining, which is training bacteria to extract metals in space, and Avalanche Biotechnologies, which is in a mid-stage clinical trial with a treatment for a blinding eye disease — call the 6,000 square feet that John leases as their shared home.

To read the original article: Slideshow: Inside Bioscience Laboratories' South of Market incubator - San Francisco Business Times