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In recent years, Berlin has become one of Germany’s—and indeed one of Europe’s—most vibrant start-up hubs. Berlin’s mayor, Klaus Wowereit, has been an enthusiastic supporter of entrepreneurs since he was first elected, in 2001. Nevertheless, many leaders believe that continued work is needed for Berlin to catch up with international start-up hubs such as London, New York, or Tel Aviv in offering optimal conditions for young firms and investors. In an interview with McKinsey’s Holger Haenecke, Katrin Suder, and Lea Thiel, Mayor Wowereit discussed his ideas on how to further encourage Berlin’s start-up dynamic.