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Ranked No. 22 among the Fortune 500, Express Scripts Holding Co. is a behemoth. But the country’s largest pharmacy benefit manager thinks tiny startups can help it find the next big idea in health care.

With $100 billion in revenue last year, the north St. Louis County-based company will invest $25 million in a multiyear deal with new local venture capital firm Lewis & Clark Ventures, which is led by serial entrepreneur Tom Hillman. The company didn’t specify over what time period it expected to make that investment.

Image: July 21, 2011- Express Scripts Research & New Solutions lab in St. Louis County. Stephanie S. Cordle This email address is being protected from spambots. You need JavaScript enabled to view it.