For academics and practitioners involved in economic development, quantifying the vibrancy of a regional innovation system can be a challenging experience. To support these efforts, new research by authors from Cleveland-based venture development organization Jumpstart and Cleveland State University’s Center for Economic Development seeks to do two things: identify key indicators – a grouping of measures representing a broader concept – for describing a vibrant entrepreneurial ecosystem, and establish which of these indicators are most valuable for entrepreneurs. Ultimately, the authors find that three broad indicators – innovation, centers of commerce, and small business hubs – can help measure entrepreneurial ecosystem vitality in a region.