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Harvard University announced on Tuesday that Hansjörg Wyss had doubled down on a contribution to his namesake Wyss Institute for Biologically Inspired Engineering at the university with a $125-million gift.

The institute was founded in 2009 with a previous $125-million gift from the Swiss-born medical-equipment mogul, who earned an M.B.A. from the university in 1965. The initial gift was reportedly the largest individual donation that Harvard had yet received. In 2004, Mr. Wyss gave $25-million to Harvard’s business school for its graduate program.