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“Drastic” federal budget cuts caused by sequestration threaten to derail major innovative breakthroughs — like an AIDS vaccine, 3D printing and digital learning — unless the Hub’s business leaders lobby Congress for change, the president of MIT told the Greater Boston Chamber of Commerce this morning.

“We need to work together — as an innovation community — to battle the single biggest threat to our future success. And that is the drastic federal budget cuts known as ‘sequestration,’” said MIT President Rafael Reif, according to his prepared remarks.