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Outbreak alert: six students at the Chicago State Polytechnic University in Illinois have been hospitalized with severe vomiting, diarrhoea and stomach pain, as well as wheezing and difficulty in breathing. Some are in a critical condition. And the university's health centre is fielding dozens of calls from students with similar symptoms.

This was the scenario that 17 third- and fourth-year undergraduates dealt with as part of an innovative virology course led by biologist Tammy Tobin at Susquehanna University in Selinsgrove, Pennsylvania. The students took on the role of federal public-health officials, and were tasked with identifying the pathogen, tracking how it spreads and figuring out how to contain and treat it — all by the end of the semester.