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cleveland

Hungry to launch his medical technology firm, Jake Orville first needed a city with the research brainpower he'd require and the workers and workspace he could afford.

Cleveland was not the sexy answer a decade ago, but it turned out to be the right one.

At Cleveland Clinic, the city's world-class health and medical facility, Orville found the diagnostic technology he wanted to commercialize and sell. In 2009, it grew into Cleveland HeartLab, a 200-person company developing biomarkers to help doctors predict cardiovascular risk.