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Gary Pisano, professor of business administration at Harvard, rejects the narrative that only scrappy startups are nimble enough to innovate. He believes large, established firms can adapt and evolve, but they have to go about it differently than their small-sized competitors.

In his new book, Creative Construction: The DNA of Sustained Innovation, Pisano offers a three-pronged approach for innovation based on more than three decades of research and consulting with companies that stayed a step ahead. He recently joined the Knowledge@Wharton radio show on SiriusXM to talk about his book and explain why innovation for big firms isn’t as simple as “be like Uber.”