Healthcare organizations face a myriad of challenges as the Covid-19 pandemic sweeps across the United States. While all businesses face marked uncertainty and a risk of infection within their workforce, the direct delivery of care to Covid-19 patients introduces an additional and novel level of leadership complexity for the healthcare industry. Healthcare workers—doctors, nurses, medical assistants, environmental services, and others—face unprecedented stress, and with this maintaining the morale and safety of all involved in the delivery of healthcare has become the most important task. We have observed several recurring themes from organizations that are effectively managing through the Covid-19 crisis and summarize a few emerging leadership principles.