COVID-19 has upended the world and our global society at a pace and in a manner that are both unprecedented. In this era of uncertainty, start-ups play an ever more important role by bringing to market innovative solutions for tackling the challenges and mitigating the negative impacts caused by the pandemic. These days, however, such solutions do not originate solely in Silicon Valley or London; they are coming from other regions of the globe with strong start-up ecosystems and unique values and cultures.