Even the experts were startled by the remarkable success of the two first-of-their-kind messenger RNA vaccines developed by Moderna and Pfizer/BioNTech against COVID-19.
"If you had told me before that there would be 95% effectiveness for these vaccines, I'd have said you were dreaming," says Andrew Pekosz, a professor in the Department of Molecular Microbiology and Immunology at the Johns Hopkins Bloomberg School of Public Health. Their adaptability for infectious threats beyond COVID-19, too, is something vaccine researchers have dreamed of.