The last two decades of technological transformation and globalization have created profound new challenges –and opportunities– for how and where innovation is located, organized, and capitalized. In this emerging global knowledge economy, the roles and responsibilities for invention, innovation, and entrepreneurship are being redefined and must be shared by the primary players; namely, universities, governments, corporations, and venture capital firms. From our perspective as a university, this begs the question: how do we ensure that exciting research is turned into profitable, real world solutions?