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The discovery of omicron — the new variant of coronavirus with a high number of concerning mutations — has kicked off a frenzy of research. Scientists are racing to figure out how transmissible this variant is and how resistant to vaccines.

They're also grappling with a mystery: How did omicron get created?

NPR spoke with two scientists in the thick of this research. Trevor Bedford is a computational virologist and professor at the Fred Hutchinson Cancer Research Center in Seattle. Richard Lessells is an infectious disease specialist at the University of KwaZulu-Natal in Durban, South Africa, and part of the team that identified omicron in South Africa and alerted the world. Here's what they have to say.