It is easy to lose sight of the importance of a commercial mindset early in the life of a biotech. Many companies fail to see or understand its value proposition or its critical role in the creation of clinical development plans. Unfortunately, because the access and reimbursement stakes are so high in this market segment, operating without a commercial lens and throwing a product over the fence to the commercial team a couple of years prior to launch with the expectation that they can take it to market and sell it are not luxuries many biotechs can afford.