BullFrog AI Holdings, Inc., a biopharmaceutical company focused on applying its proprietary Artificial Intelligence/Machine Learning platform to improve drug development and shorten clinical trial timelines, today announced that it has entered into an exclusive license agreement with Johns Hopkins University for use of its novel formulation of mebendazole in treating cancer.
Under the terms of the agreement, BullFrog AI was granted an exclusive worldwide license to manufacture and use a novel formulation of mebendazole developed at the Johns Hopkins University (JHU) School of Medicine for treatment of cancer. This formulation is enriched in a polymorph of the drug which shows improved bioavailability, is particularly effective in crossing the blood-brain barrier, and has shown potent antitumor activity in multiple animal models of different cancers. In addition, it has been evaluated in a Phase I clinical trial in patients with high-grade gliomas (NCT01729260). The trial, an open-label dose-escalation study, enrolled 24 patients and demonstrated long-term safety and acceptable toxicity of mebendazole with adjuvant temozolomide in this population.
