A startup company is developing a flat-panel source of x-rays that could help make the imaging technique portable. The company's panels are made using techniques commonplace in the semiconductor industry and would be combined with flat-panel image sensors to make a briefcase-sized x-ray machine powered by a laptop battery. Such a system might be used in the field by the military or instead of bulky bedside systems used in hospital intensive-care units. Early research also suggests it might expose patients to less radiation.

The company behind the x-ray source, Radius Health, was spun out of the University of California, Los Angeles last year. It is developing a commercial version of a flat-panel x-ray source developed by physicists at the university. The company will make its first complete x-ray imager in three to four months and says it will have a full-scale prototype in a year.

The x-ray machines used in hospitals today employ a high-energy source of the radiation. A tungsten filament at one end of a long vacuum tube emits electrons when heated and those accelerate down the tube until they hit a metal electrode, causing it to produce x-rays.

Dave Duffield is back in a cubicle after building PeopleSoft into a giant, then losing it in a brutal takeover battle with Larry Ellison. How at 70 he's planning his return — and his IPO.

David Duffield has earned a comfortable retirement; over the course of his nearly 70 years he’s started several companies, helped define today’s business software market, and become a billionaire. But you won’t find him on the golf course. Not only is Duffield still a working stiff, he’s in the Silicon Valley startup game as co-CEO of Workday.

Why would a guy with a billion dollars in the bank still report to his cubicle every morning? (Yes, it's an actual cubicle.) For one thing, he says his latest business idea was just too good to pass up. But mainly, he just seems to love working.

After he lost his last company – human resources software maker PeopleSoft – to Oracle in a brutal takeover battle, it only took a couple of months before he and old buddy Aneel Bhusri began laying the groundwork for another venture. Here’s Workday in a nutshell: It’s the software you need to manage people in a big company, but delivered through a web browser. Think of it as Salesforce.com for employee records.

Eight years ago, Hamilton Chan faced the daunting task of turning around his father's 30-year-old commercial printing business and shoring up its flagging customer base. Five years later, the Los Angeles company he had grown up working in was back in the black.

So Chan started all over, founding a second company, online stationery seller Paperspring.com. He is CEO of both companies and employs 22, with three individuals working solely for Paperspring and "lots of overlap" among the others.

When is one company just not enough? In Chan's case, the moment arrived when he needed a new challenge.

"When you inherit a legacy business, you're still jonesing to create something of your own," says Chan, a Harvard-educated lawyer and investment banker. "You really learn from past mistakes and you develop experience as an entrepreneur that you'd love to parlay into something that would be ideal—if only you could start from scratch."

Starting your own business can be one of the best decisions you ever make in your life. There are many advantages to starting your own business such as independence and control over your potential salary. While all of these benefits are great, there is a lot of misinformation about what it takes to become an entrepreneur. (Find out if you have what it takes in Are You An Entrepreneur?)

In Pictures: 8 Tips For Starting Your Own Business

Have you ever been told that it takes a lot of money to start a business? Have you ever been told that you need a MBA to start a company? Myths like these keep potential business owners from taking the plunge into entrepreneurship and becoming their own bosses. You may think that you know all of the basics for starting a business but what you believe may in fact be wrong.

It now takes almost as long to get a job in the U.S. — seven and a half months — as it does to produce your next of kin. That’s the longest slog since the Labor Department began tracking job search duration in 1948. Looked at another way, there are currently an average of six people vying for every job that you are, each of them doing exactly the same things — combing job boards, networking, prepping for interviews — as you. Is there a way to speed up the job search and stand out from your competition?

Recruiters and other experts say that the only way is to put in the extra work to present yourself so that employers realize they absolutely need you, and that they need you right now.

Mary Berman managed to do it. After interviewing last fall for a job she really wanted in event management and marketing, the 56-year-old Berman decided to ditch the typical thank-you note and instead spent the whole night after the interview creating a detailed action plan for her first 30, 60, and 90 days in the job. She described to her future boss how she would learn the job, build rapport with employees and customers, contribute to the company’s bottom line, and fulfill every function outlined in the job description. And it didn’t hurt that she had already sent the person she first interviewed with, as well as the office receptionist, a chocolate-dipped apple to go with her thank-you note. Three days later, Berman heard back with an offer — just two months after she started her job search.

American venture capitalists are notoriously fickle water investors.

Recognizing that water is a rapidly expanding $400 billion global market, many investors pledge a theoretical interest in water innovations. But in practice, window shopping is the norm.  Concerned about the capital intensity of many water projects and the length of water startups' time to market and sales cycles, numerous American venture firms have made only a single water investment. As a result, many firms are not well prepared to evaluate and embrace the next great water startup. 

"If you have done just one, you don't know the 100 different pieces of the value chain and the market segment," says CMEA Capital's Rachel Sheinbein, who used to help Intel address wastewater challenges. "Something else comes in and it is totally different. It is like saying 'energy.' There are so many pieces of [the water market]." 

North of the border, in Canada, there is a lot less hesitation. 

My upcoming book, The New Polymath due in June, has case studies on Kleiner Perkins, salesforce.com, Plantronics and plenty of discussions of Google, Apple and other Valley innovators. But it also showcases plenty of innovation in places in the rest of the globe.

Here are a few of the many examples across the book (and plenty more in book on Brazil, Israel, S. Korea and 30 more countries):

• Estonia, in a hurry to escape its communist detour, is one of the most “wired” countries in the world. It’s “Tiigrihüppe” (tiger leap) initiative provides a prototype of the digital life citizens in most other countries will achieve in a decade. More than 90% of bank transactions are conducted online. Tallinn (the capital)’s citizens pay for their parking tickets and their bus passes by sending text messages from their mobile phones. They elect their representatives from their home computers. Parliamentary and town hall debates are now recorded without producing any paper trail.

First of all, I would like to thank the Spanish Presidency of the European Union for organizing this important and timely forum.

I would also like to congratulate the organisers for their decision to invite such a broad array of stakeholders from the cultural sector, business and education.

The cultural and creative industries cut across many social and economic areas, and the broad debate that has animated this forum is a proof of it.

So, it was a good decision to give everyone the opportunity to share their views. It is important for all of us in our different spheres of action to find a way to work together towards shared objectives.

Many issues have been raised over the past two days by the different speakers.

• We’ve heard about access to funding, capacity building, and skills development.
• We’ve heard about the need to open up a common European space to help cultural and creative industries develop locally and go global.
• We’ve heard about initiatives that are aimed to unlock the potential of cultural and creative industries in our countries, regions and cities.

Author: Androulla VASSILIOU, European Commissioner responsible for Education, Culture, Multilingualism and Youth

Download the PDF here.

More than 1 out of 10 adult workers are self-employed, and that number tends to go up in a recession. To anyone yoked to a traditional nine-to-five job, the idea of being your own boss and working from home might sound like heaven. The truth is, freelancing isn't easy. After seven years of self-employment, I've found the three biggest challenges 1099ers face are managing time, money, and expectations.

The first question every employee asks when they find out you work from home is: How do you avoid the distractions of being at home? If no one's stopping you from wandering into the living room midday to watch Days of Our Lives, what motivates you to work instead? Freelancers have to be extra mindful of how they spend their time and set up ways to transition between home and work mode without a commute. The best way to switch gears is to create a space dedicated to work and work only. Ideally this will be a home office with a door on it, but even a dedicated desk and computer in a corner of a room will do. The key is to train your brain that when you're in this space, it's time to work.

Managing your money isn't easy when you get the same amount of money in a steady paycheck every two weeks. But when you're a freelancer, things get exponentially more complicated. A freelancer is usually in one of two financial modes: feast or famine. It can be stressful, too. A recent survey showed that while freelancers are more satisfied with their jobs than nine-to-fivers, they also shoulder more financial stress. The survival skill here is to reduce money stress with a financial safety net, or buffer accounts, that you feed during feast days and draw on during famine.

In this challenging fundraising environment, private equity ("PE") managers have shown increased interest in obtaining capital through the Small Business Investment Company ("SBIC") program, which provides attractive loans to PE firms licensed by the Small Business Administration (the "SBA") for the purpose of financing small businesses.

The SBIC program offers a PE fund access to SBA leverage, enabling the PE fund to:

• Borrow at rates generally lower than traditional lending sources (September 2009 SBA leverage was priced at just over 4%);^[1]
• Increase the size of its fund (to the sum of limited partner ("LP") capital plus SBA leverage);
• Reduce the number of capital calls from LPs (by drawing SBA leverage for interim capital needs); and
• Thereby enhance LP returns.

The February 2009 American Recovery and Investment Act, commonly referred to as the Stimulus Bill, increased the maximum amount of SBA leverage available to an SBIC from approximately $137 million to $150 million (or $225 million for a group of affiliated SBICs). Because an SBIC may generally borrow two (and possibly three) times its committed capital, a $50 million fund may become a $150 million (and possibly $200 million) fund through SBA leverage.

Dennis Crowley has it very, very good -- and we can prove it.

Dennis is the CEO and cofounder of Foursquare, a mobile "check-in" service that will cross the million user mark faster than Twitter did.

This popularity has led brand name venture capitalists (Khosla, Accel, and Andreessen Horowitz) to prepare to give Foursquare money at a super-high valuation ($80 million? $100 million?).

This question comes up a lot especially amongst small business owners and entrepreneurs:  How do I make money from blogging?

The bottom line is there are TONS of ways to make money directly and indirectly from your blog including selling a product or service, sponsorships and tasteful (keyword tasteful) advertising (that is what we do), affiliate marketing and many more.

That being said, the most successful blogs aren’t advertisements. They aren’t a bullhorn telling people to buy, buy, buy! The top end of blogs are educational and informative as opposed to hard selling. Meaning they are focused around a topic, not a product.

But let’s not forget the purple elephant in the room for business owners: We want to make money. Money is a good thing.

-- EXAMINE VIDEO FOR INCLUSION --

For Maine businesses to thrive, they must innovate. And for the University of Maine System to produce the workers those businesses need, the system must innovate as well.

That was the message Tuesday from a daylong summit aimed at fostering ideas to match Maine's university programs with the state's economic needs.

"The only strategy is innovation," said Doug Hall, chief executive officer of Eureka! Ranch, a Cincinnati-based think tank that focuses on business innovation. "Innovation means greater survival."

The event, held at the University of Maine in Orono, featured speakers, more than 200 university professors, officials and a handful of representatives from business, health care, government and nonprofits.

The medicine cabinet of the future could help make sure patients take their medications on time via a myriad of smart technologies. There are already pill bottles that wirelessly report to a computer when a cap has been opened, and devices for automatically dispensing medicine at the right time, and for reminding patients to take their meds.

Now researchers at the University of Florida have engineered a smart pill with a tiny antenna and microchip that could signal when it has made it into a patient's stomach--reporting to a cell phone or computer that she has taken her medicine. Their design is the latest of several high-tech pill-reporting efforts to improve patient adherence and provide accurate reporting.

The prototype pill is composed of a standard pill capsule, wrapped in a thin label etched in silver nano-ink, comprising an antenna. The team also outfitted the label with a tiny microchip, which can be loaded with sensors to detect measurements like body temperature or pH levels. Both the antenna and microchip communicate with an external transmitter, which researchers say could be fashioned into a wearable device such as a wristband. The transmitter sends low frequency pulses into the body; the pill's antenna tunes into the transmitter's specific frequency, and sends pulses back, along with data collected from the microchip, potentially including the time when the patient ingested the pill, and the type of pill taken.

Wondering whether it's a good idea to ride your bike to work? Bicycling Magazine has put together a handy list of the top 50 bike friendly cities in the U.S. (Spoiler alert) Congratulations, Minneapolis, Minn.! Some of the choices are obvious--the list would be suspect if cities like San Francisco, Portland, and New York City weren't included--but others might surprise you. Did you know, for example, that over 5% of Gainesville, Florida, residents commute by bike (it's a town built around the University of Florida, after all)? Or that Fargo, North Dakota, has over 200 miles of bike paths?

All of the cities listed have populations of 100,000 or more, and California kind of got the shaft--Bicycling Magazine aimed for geographic diversity "to avoid having a list dominated by California’s many bike-oriented cities." We would also like to see some kind of ranking--surely some of these cities are superior to others. The list is handy overall, though, and clicking on each city reveals why it was picked. The magazine also has a separate list of the top 5 biking cities with populations of 100,000 of less for claustrophobic riders.

Rob Go is an associate at Spark Capital, and has a great blog on Tumblr about venture capital and startups. On his blog, he recently asked who are the top entrepreneur bloggers.

Rob and his commenters have some great suggestions, but help us help Rob by telling us who are the best entrepreneur bloggers.

Chris Dixon, founder of SiteAdvisor and Hunch, serial angel investor, first personally (Skype!) and now through Founder Collective, is first on Rob's list, and with good reason. He is a very impressive guy and his blog is absolutely excellent and must-read.

A top Commerce Department official Tuesday vowed to unclog the country’s beleaguered patent office, linking efforts to clear hundreds of thousands of patent applications to creating jobs and reducing America’s trade deficit.

In an interview with MedCity News, David Kappos, Undersecretary of Commerce for Intellectual Property who directs the United States Patent and Trademark Office (USPTO), said the Obama administration hopes to add more than 2,200 patent examiners over the next three years and overhaul the office’s aging computer systems.

“Innovation has become the centerpiece of the American economy,” Kappos said. “And patents are the currency of innovation. We’re not going to be a low-cost manufacturing economy. People understand the one thing that protects innovations and that’s intellectual property.”

When they started their business, a lack of capital was a worry for partners Mary Rogers and Rosemary Hartnett.

The pair planned to start an Abrakadoodle franchise -- a community center, school and day care program for children 2 to 12 -- but a lack of money would have delayed their Reston franchise from opening.

"We were looking to launch the business," Rogers said. "We didn't have a lot of capital to do this."

So, in 2002, she and Hartnett applied to INC.spire, a business incubator run by the Greater Reston Chamber of Commerce that helps companies get started.

U2 singer Bono's stake in Elevation Partners has helped make him the "worst investor investor in America," according to the online publication 24/7 Wall Street.

U2 -- arguably the world's most popular rock 'n' roll band -- will perform June 12 at Denver's Invesco Field at Mile High.

With large investments in Palm, Forbes, and Move.com -- "an unprecedented string of disastrous investments which even bad luck could not explain" -- Elevation Partners has earned the distinction of being "arguably the worst run institutional fund of any size in the United States," 24/7 Wall Street asserts.

Reviewers have weighed in on the iPad. The consensus verdict is that Apple's tablet-style computing device is a stylish, versatile tool for e-reading, media viewing, and communicating—but it falls short as a full-on laptop or netbook replacement.

Veteran Wall Street Journal tech critic Walter Mossberg has been testing the iPad for the past week. The device has "the potential to change portable computing profoundly," Mossberg wrote, in a column published Thursday.

"If you're mainly a Web surfer, note taker, social networker and emailer, and a consumer of photos, videos, books, periodicals and music—this could be for you," wrote Mossberg.

"If you need to create or edit giant spreadsheets or long documents, or you have elaborate systems for organizing email, or need to perform video chats, the iPad isn't going to cut it as your go-to device," said Mossberg.